| Expression pattern: |
DN |
| Associated gene: |
FOXO1, PCNA, Bcl-2, Bax, Ki67 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
circ_BLNK acts as a tumor suppressor in NSCLC, inhibiting proliferation, viability, colony formation, migration, invasion and tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
circ_BLNK functions as a ceRNA/miRNA sponge for miR-942-5p, thereby indirectly increasing FOXO1 expression and suppressing NSCLC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; MTT; EdU Staining; Colony Formation Assay; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Low expression of circ_BLNK predicts a poor prognosis and circ_BLNK may be a promising marker, therapeutic target, and diagnostic application for NSCLC. |
| Description: |
circ_BLNK is down-regulated in NSCLC tissues and cells and behaves as a tumor suppressor. Its overexpression inhibits malignant phenotypes and xenograft tumor growth by sponging miR-942-5p and relieving repression of FOXO1, forming a circ_BLNK/miR-942-5p/FOXO1 regulatory axis with potential diagnostic and therapeutic relevance. |
| Confidence score: |
0.7955 |