circRNA basic information
circBase ID: hsa_circ_0007766
Name: hsa_circ_ERBB2
Synonym: circ-ERBB2
Host Gene: ERBB2
Genomic location(hg19): chr17:37864573-37866734:+
Genomic location(hg38): chr17:39708320-39710481:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissues; adjacent normal tissues
Cell lines:

HBE; SK-MES-1; H1650; Calu-3; H460; H1299; A549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: miR-7-5p
Biological function: Promotes lung cancer cell proliferation, invasion and glycolysis and inhibits apoptosis; propofol suppresses these malignancies partly by downregulating circ-ERBB2. circ-ERBB2 knockdown enhances propofol’s tumor-suppressive effect in vivo.
Molecular mechanism: ceRNA mechanism: circ-ERBB2 sponges miR-7-5p, relieving miR-7-5p-mediated repression of FOXM1; propofol decreases circ-ERBB2 to modulate the circ-ERBB2/miR-7-5p/FOXM1 axis.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-ERBB2 is up-regulated in lung cancer tissues and cell lines, and propofol reduces its expression. Mechanistically, circ-ERBB2 sponges miR-7-5p to increase FOXM1, thereby promoting malignant phenotypes including proliferation, invasion and glycolysis and reducing apoptosis; circ-ERBB2 knockdown enhances propofol’s antitumor effects in xenografts.
Confidence score:

0.742
Other information
Title:

Propofol suppresses lung cancer tumorigenesis by modulating the circ-ERBB2/miR-7-5p/FOXM1 axis.

Journal: Thoracic cancer
Published: 2021
PubMed ID: 33506582
Study type:

combined biological and clinical study
Data availability: GSE158695
Code availability: -