circRNA basic information
circBase ID: hsa_circ_0004370
Name: hsa_circ_PRRX1
Synonym: circ_0004370
Host Gene: PRRX1
Genomic location(hg19): chr1:170688866-170695542:+
Genomic location(hg38): chr1:170719725-170726401:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007576
MONDO name: esophageal cancer
Disease details: esophageal cancer
Disease DO ID:
 5041
Disease MeSH ID:
 -
Disease NCIt ID:
 C7478
Disease ICD11 ID:
 669033105
Disease OMIM ID:
 133239
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissues; nearby healthy esophageal tissues; adjacent normal tissues
Cell lines:

OE19; KYSE410; EC109; TE11; HEEC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: COL1A1
Associated microRNA: miR-1301-3p
Biological function: Promotes EC cell proliferation/viability, migration, invasion, EMT, and tumor growth; inhibits apoptosis.
Molecular mechanism: Acts as a ceRNA by sponging miR-1301-3p, thereby relieving miR-1301-3p-mediated repression of COL1A1.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circ_0004370 expression was correlated with clinicopathological features (TNM stages, tumor size) in ESCC patients; proposed as a potential therapeutic target.
Description:

circ_0004370 is up-regulated in esophageal cancer tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while inhibiting apoptosis by sponging miR-1301-3p to upregulate COL1A1.
Confidence score:

0.7799
Other information
Title:

CircRNA circ_0004370 promotes cell proliferation, migration, and invasion and inhibits cell apoptosis of esophageal cancer via miR-1301-3p/COL1A1 axis.

Journal: Open medicine (Warsaw, Poland)
Published: 2021
PubMed ID: 33506107
Study type:

combined biological and clinical study
Data availability: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -