circRNA basic information
circBase ID: hsa_circ_0006168
Name: hsa_circ_CNOT6L
Synonym: circ_0006168
Host Gene: CNOT6L
Genomic location(hg19): chr4:78694234-78697546:-
Genomic location(hg38): chr4:77773080-77776392:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; adjacent normal tissues; tumor tissues
Cell lines:

HET-1A; Eca109; KYSE450; KYSE150; KYSE30; Eca109/Taxol; KYSE150/Taxol
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: JMJD1C, Ago2
Associated microRNA: miR-194-5p
Biological function: Promotes Taxol resistance and tumor growth; promotes proliferation, migration and invasion; inhibits apoptosis.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-194-5p to increase JMJD1C expression, thereby enhancing Taxol resistance in ESCC.
Biological pathway or process:

chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0006168 is up-regulated in ESCC tissues/cells and further elevated in Taxol-resistant ESCC cells. It promotes Taxol resistance and malignant phenotypes by sponging miR-194-5p to upregulate JMJD1C, and its knockdown increases Taxol sensitivity and suppresses xenograft tumor growth.
Confidence score:

0.7794
Other information
Title:

Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis.

Journal: Cancer cell international
Published: 2021
PubMed ID: 34022910
Study type:

combined biological and clinical study
Data availability: The online version contains supplementary material available at 10.1186/s12935-021-01984-y; The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -