| Expression pattern: |
DN |
| Associated gene: |
FOXM1 |
| Associated microRNA: |
miR-1244 |
| Biological function: |
Limits trophoblast cell proliferation and migration; circUBAP2 knockdown suppresses proliferation and migration and increases apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1244 to regulate FOXM1 expression; rescue with miR-1244 inhibitor reverses effects of circUBAP2 knockdown. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Downregulated in placental tissues from patients with PE; proposed as a promising molecular marker for diagnosis and treatment of PE. |
| Description: |
circUBAP2 is down-regulated in placental tissues from preeclampsia patients. Functional assays show that circUBAP2 supports trophoblast proliferation and migration, and mechanistically acts as a ceRNA by sponging miR-1244 to regulate FOXM1; miR-1244 inhibition partially rescues the effects of circUBAP2 knockdown. |
| Confidence score: |
0.7795 |