| Expression pattern: |
UP |
| Associated gene: |
WNT7B, SLC1A5, RCBTB1, COL6A6 |
| Associated microRNA: |
hsa-miR-197-3p, hsa-miR-370-3p, hsa-miR-377-5p |
| Biological function: |
inhibits apoptosis and promotes proliferation, migration and invasion of CRC cells |
| Molecular mechanism: |
Acts as a miRNA sponge for hsa-miR-370-3p, thereby upregulating WNT7B (and positively correlating with COL6A6, RCBTB1, SLC1A5, WNT7B). |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In colorectal cancer, circIFT80 (hsa-circRNA-0067835) is up-regulated and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges hsa-miR-370-3p to upregulate WNT7B and is positively associated with COL6A6, RCBTB1 and SLC1A5 expression. |
| Confidence score: |
0.6536 |