| Expression pattern: |
UP |
| Associated gene: |
XRCC1, CYP1A1 |
| Associated microRNA: |
miR-486-3p |
| Biological function: |
promotes viability, proliferation, migration, and invasion of lung cancer cells; promotes tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circFLNA sponges miR-486-3p and thereby up-regulates XRCC1 and CYP1A1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circFLNA (hsa_circ_0092012) is up-regulated in lung cancer tissues/cells and mainly localized in the cytoplasm. It promotes lung cancer cell proliferation, migration and invasion and enhances xenograft tumor growth by sponging miR-486-3p, leading to increased XRCC1 and CYP1A1 expression. |
| Confidence score: |
0.742 |