| Expression pattern: |
UP |
| Associated gene: |
AGO2, GRAMD1A |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes HCC cell proliferation, migration and invasion; promotes xenograft tumor growth |
| Molecular mechanism: |
acts as a miRNA sponge for miR-1294 to up-regulate GRAMD1A |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
might be a potential prognosis and therapeutic target for HCC |
| Description: |
circCAMSAP1 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1294, thereby increasing GRAMD1A expression. |
| Confidence score: |
0.7564 |