| Expression pattern: |
UP |
| Associated gene: |
DLGAP5, MCM5, MCM6, MCM3, CDC20, CCNB1, CDC7 |
| Associated microRNA: |
hsa-miR-455-5p, hsa-miR-615-3p |
| Biological function: |
unknown |
| Molecular mechanism: |
Putative miRNA sponge (ceRNA) in a circRNA-miRNA-mRNA network (hsa-miR-455-5p and hsa-miR-615-3p) affecting hub genes involved in DNA replication and cell cycle. |
| Biological pathway or process: |
cell cycle (promotes); DNA replication (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Agarose gel electrophoresis; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker in tissue and plasma for HCC (up-regulated in both). |
| Description: |
hsa_circ_0009910 is up-regulated in HCC tissue and plasma and was experimentally validated as a circular, RNase R-resistant transcript that can be excreted into hepatoma-cell culture medium. It is proposed to act in a circRNA-miRNA-mRNA (ceRNA) network by interacting with hsa-miR-455-5p and hsa-miR-615-3p to modulate cell-cycle/DNA-replication hub genes (e.g., MCM family, CCNB1, CDC20, CDC7, DLGAP5). |
| Confidence score: |
0.6193 |