| Expression pattern: |
UP |
| Associated gene: |
RNF38 |
| Associated microRNA: |
miR-7 |
| Biological function: |
promotes proliferation, migration, invasion, EMT and tumorigenesis; inhibits apoptosis (knockdown increases apoptosis) |
| Molecular mechanism: |
ceRNA sponge of miR-7, thereby modulating RNF38 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; CCK8; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_LDLR is up-regulated in hepatocellular carcinoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion and EMT while inhibiting apoptosis, at least partly by sponging miR-7 to derepress RNF38 (circ_LDLR/miR-7/RNF38 axis). circ_LDLR depletion suppresses xenograft tumor growth in vivo. |
| Confidence score: |
0.7419 |