circRNA basic information
circBase ID: hsa_circ_0001649
Name: hsa_circ_SHPRH
Synonym: -
Host Gene: SHPRH
Genomic location(hg19): chr6:146209155-146216113:-
Genomic location(hg38): chr6:145888019-145894977:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paracancerous histological normal tissues (PCHNTs); serum; whole blood
Cell lines:

SGC-7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for gastric cancer; AUC 0.834; associated with pathological differentiation
Description:

hsa_circ_0001649 (host gene SHPRH) is significantly down-regulated in gastric cancer tissues versus paired nontumorous tissues, and increases in serum after surgery. It shows diagnostic potential for GC (ROC AUC 0.834) and is associated with pathological differentiation, but no molecular mechanism was experimentally defined.
Confidence score:

0.6238
Other information
Title:

Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance.

Journal: Disease markers
Published: 2017
PubMed ID: 28167847
Study type:

combined biological and clinical study
Data availability: -
Code availability: -