| Expression pattern: |
UP |
| Associated gene: |
HK2, Ago2 |
| Associated microRNA: |
miR-501-3p |
| Biological function: |
promotes viability, migration, invasion, glycolysis and radioresistance; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ-ZNF609 sponges miR-501-3p to up-regulate HK2, promoting glycolysis and radioresistance |
| Biological pathway or process: |
glycolysis (promotes); radioresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
providing promising targets for improving the prognosis of PCa patients |
| Description: |
circ-ZNF609 is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes and radioresistance. Mechanistically, it sponges miR-501-3p to increase HK2 expression, enhancing glycolysis and thereby decreasing radiosensitivity; circ-ZNF609 knockdown reverses these effects in vitro and in xenograft tumors. |
| Confidence score: |
0.705 |