circRNA basic information
circBase ID: -
Name: hsa_circ_PDE4B
Synonym: circPDE4B
Host Gene: PDE4B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005556
MONDO name: lupus nephritis
Disease details: lupus nephritis
Disease DO ID:
 0080162
Disease MeSH ID:
 D008181
Disease NCIt ID:
 C34789
Disease ICD11 ID:
 1815692673
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

renal biopsy tissues / kidney tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with LN disease activity parameters (correlative).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation
Clinical significance:

Significantly correlated with one or two clinical parameters of LN disease activity.
Description:

circPDE4B is significantly up-regulated in LN renal biopsies and correlates with LN disease activity parameters; the study does not further validate its molecular mechanism.
Confidence score:

0.5129
Other information
Title:

circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.

Journal: Molecular therapy. Nucleic acids
Published: 2018
PubMed ID: 29499937
Study type:

combined biological and clinical study
Data availability: Supplemental Information (two figures and four tables) at https://doi.org/10.1016/j.omtn.2017.12.006
Code availability: -