| Expression pattern: |
UP |
| Associated gene: |
Sox9 |
| Associated microRNA: |
miR-583 |
| Biological function: |
regulates extracellular matrix metabolism and cell apoptosis in NPCs (via miR-583/Sox9) |
| Molecular mechanism: |
ceRNA mechanism: circ-FAM169A sponges miR-583, affecting Sox9 expression |
| Biological pathway or process: |
apoptosis (other); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Western Blot; Transfection; Clinical Sample Validation |
| Clinical significance: |
may provide novel diagnostic biomarkers and develop effective treatment strategy of IDD diseases |
| Description: |
circ-FAM169A is up-regulated in degenerative human NP tissues in IDD. It localizes to the cytoplasm and acts as a ceRNA that directly sponges miR-583, thereby influencing the miR-583 target Sox9 and potentially modulating ECM metabolism and apoptosis in NPCs. |
| Confidence score: |
0.659 |