| Expression pattern: |
DN |
| Associated gene: |
AKT/mTOR signaling pathway, p-AKT, p-mTOR, Bax, Bcl-2, MMP-9, cyclin D1 |
| Associated microRNA: |
hsa-miR-593, hsa-miR-383, hsa-miR-188-3p |
| Biological function: |
Suppresses OSCC malignant behaviors by inhibiting proliferation, migration and invasion and promoting apoptosis; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Modulates AKT/mTOR signaling by altering phosphorylation levels of AKT and mTOR (p-AKT, p-mTOR); predicted to sponge several miRNAs (not experimentally validated). |
| Biological pathway or process: |
AKT/mTOR (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RNA-seq; Microarray; RT-qPCR; RNase R Treatment; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Downregulation is closely related to lymph node metastasis; indicates prognosis and may be a potential prognostic/therapeutic target for OSCC. |
| Description: |
hsa_circ_0007059 is down-regulated in OSCC tissues and cell lines. Its overexpression suppresses proliferation, migration and invasion while promoting apoptosis, and it inhibits xenograft tumor growth, at least partly by reducing p-AKT and downstream p-mTOR levels (AKT/mTOR pathway). |
| Confidence score: |
0.6977 |