| Expression pattern: |
UP |
| Associated gene: |
TBX15 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes proliferation, migration, invasion, tumor growth and metastasis |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-145-5p, relieving repression of TBX15 and promoting ccRCC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; divergent primers PCR; RT-qPCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; RNA Pull-Down; Luciferase Reporter Assay; RNA-seq; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circPVT1 is overexpressed in ccRCC tissues and serum, associated with T/N/M stage, and shows diagnostic value with ROC AUC 0.93 (tissue) and 0.86 (serum). |
| Description: |
circPVT1 (hsa_circ_0001821), derived from PVT1, is up-regulated in ccRCC tissues and serum and is associated with advanced stage. Functionally, it promotes ccRCC proliferation, migration/invasion, and in vivo tumor growth/metastasis. Mechanistically, it acts as a ceRNA sponging miR-145-5p to upregulate TBX15. |
| Confidence score: |
0.8802 |