| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR‐17‐5p, miR‐630 |
| Biological function: |
Inhibits prostate cancer cell proliferation and invasion; associated with less severe pathological T/N stage and favorable survival profiles. |
| Molecular mechanism: |
circ-MTO1 overexpression downregulates miR-17-5p expression in prostate cancer cells (direct targeting cited from previous studies; mechanistic validation in this study not performed). |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
High circ-MTO1 expression in tumor tissue correlates with decreased pathological T/N stage and independently predicts longer DFS and OS. |
| Description: |
circ-MTO1 is down-regulated in prostate cancer tumor tissue and acts as a tumor suppressor by inhibiting proliferation and invasion in PC-3 cells. Clinically, higher tumor circ-MTO1 is associated with lower pathological T/N stage and independently predicts longer DFS and OS, and its overexpression reduces miR-17-5p levels. |
| Confidence score: |
0.7081 |