| Expression pattern: |
UP |
| Associated gene: |
FUT2 |
| Associated microRNA: |
miR-4428 |
| Biological function: |
promotes ECM degradation and chondrocyte apoptosis; aggravates inflammation; promotes OA progression |
| Molecular mechanism: |
ceRNA (miRNA sponge): circCSNK1G1 sponges miR-4428, relieving repression of FUT2 |
| Biological pathway or process: |
apoptosis (promotes); fibrosis (not specified); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; TUNEL; ELISA; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
circCSNK1G1 is up-regulated in osteoarthritis cartilage and promotes OA progression by enhancing inflammation, extracellular matrix degradation and chondrocyte apoptosis. Mechanistically, it acts as a miRNA sponge for miR-4428, thereby derepressing the miR-4428 target FUT2 (circCSNK1G1/miR-4428/FUT2 ceRNA axis). |
| Confidence score: |
0.7052 |