circRNA basic information
circBase ID: -
Name: hsa_circ_LIFR
Synonym: circRNA LIFR
Host Gene: LIFR
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003175
MONDO name: salivary gland adenoid cystic carcinoma
Disease details: salivary adenoid cystic carcinoma
Disease DO ID:
 4866
Disease MeSH ID:
 -
Disease NCIt ID:
 C8026
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

SACC tissues; matched normal tissues; para-carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-520a-5p
Biological function: unknown
Molecular mechanism: Predicted circRNA LIFR-miR-520a-5p interaction was not supported by qRT-PCR for miR-520a-5p (reported inconsistency with prediction).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA LIFR is down-regulated in SACC and its expression change was validated by RT-qPCR. It was bioinformatically predicted to interact with miR-520a-5p, but qRT-PCR results for miR-520a-5p did not agree with the predicted negative relationship, and no functional role was established.
Confidence score:

0.4032
Other information
Title:

Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.

Journal: Cancer cell international
Published: 2021
PubMed ID: 33413420
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -