| Expression pattern: |
UP |
| Associated gene: |
MAP3K8, AGO2 |
| Associated microRNA: |
miR-93-5p |
| Biological function: |
Promotes osteoarthritis progression by increasing oxidative stress (ROS), inflammation, and extracellular matrix degradation in chondrocytes. |
| Molecular mechanism: |
Acts as a ceRNA that sponges miR-93-5p to upregulate MAP3K8, activating MEK/ERK1/2 and NF-kappaB signaling and thereby promoting oxidative-stress-triggered inflammation and ECM loss. |
| Biological pathway or process: |
ERK (promotes); NF-kappaB (promotes); inflammation (promotes); oxidative phosphorylation (unclear); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; divergent primers PCR; Sanger Sequencing; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; ELISA; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; Bioinformatics Analysis; IHC (Immunohistochemistry) |
| Clinical significance: |
Upregulated in OA articular cartilage from elderly individuals; proposed potential therapeutic target for OA. |
| Description: |
circRSU1 is up-regulated in oxidative-stress/inflammation-stimulated human chondrocytes and in OA cartilage from elderly patients. It promotes ROS production, inflammatory cytokines, and ECM degradation by sponging miR-93-5p to increase MAP3K8 and activate MEK/ERK1/2 and NF-kappaB signaling; overexpression aggravates OA-like changes in a mouse OA model. |
| Confidence score: |
0.8537 |