| Expression pattern: |
UP |
| Associated gene: |
Vimentin, AGO2 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
Promotes cervical cancer cell migration and invasion/metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-138-5p, thereby enhancing Vimentin expression. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
High circGSE1 is positively correlated with adverse clinicopathological features and predicts worse overall survival and disease-free survival; may act as a diagnostic biomarker for disease progression of cervical cancer. |
| Description: |
circGSE1 (hsa_circ_0000722), derived from the GSE1 gene, is up-regulated in cervical cancer and mainly localized in the cytoplasm. It promotes cervical cancer cell migration and invasion by sponging miR-138-5p, thereby relieving repression of Vimentin. High circGSE1 correlates with aggressive clinicopathological features and poorer OS/DFS. |
| Confidence score: |
0.8679 |