circRNA basic information
circBase ID: hsa_circ_0061395
Name: hsa_circ_BACH1
Synonym: -
Host Gene: BACH1
Genomic location(hg19): chr21:30698379-30702014:+
Genomic location(hg38): chr21:29326058-29329693:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues; serum; serum-derived exosomes; mice tumor tissues
Cell lines:

SNU-387; Huh-7; THLE-2; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PIK3R3
Associated microRNA: miR-877-5p
Biological function: Promotes proliferation, invasion, and migration; inhibits apoptosis; promotes cell cycle progression; promotes tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-877-5p to increase PIK3R3 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

circ_0061395 expression was associated with the tumor size, TNM stages, and lymphatic metastasis of HCC patients.
Description:

hsa_circ_0061395 (circ_0061395), derived from BACH1, is up-regulated in HCC tissues, serum, and serum-derived exosomes. It promotes HCC malignant phenotypes and tumor growth by sponging miR-877-5p to increase PIK3R3 expression (ceRNA axis).
Confidence score:

0.7594
Other information
Title:

Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis.

Journal: Cancer cell international
Published: 2021
PubMed ID: 33407443
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -