| Expression pattern: |
UP |
| Associated gene: |
YY1, Ago2 |
| Associated microRNA: |
miR‐556‐5p, miR‐567 |
| Biological function: |
promotes cell growth/proliferation, migration, invasion and metastasis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ-LAMP1 sponges miR-556-5p and miR-567 to relieve repression of YY1 at the post-transcriptional level |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-LAMP1 expression is associated with clinical severity, high post-operative recurrence and poor prognosis, and is an independent prognostic indicator for OS/DFS in CCA. |
| Description: |
circ-LAMP1 is up-regulated in cholangiocarcinoma and predominantly localized in the cytoplasm. It promotes CCA proliferation, invasion and metastasis and inhibits apoptosis by acting as a ceRNA that sponges miR-556-5p and miR-567, thereby up-regulating YY1. High circ-LAMP1 expression is associated with recurrence and poor survival in CCA patients. |
| Confidence score: |
0.8737 |