| Expression pattern: |
DN |
| Associated gene: |
CACNA2D2 |
| Associated microRNA: |
hsa-miR-4262 |
| Biological function: |
potential biomarker of PDCM; may contribute to PDCM pathogenesis via post-transcriptional regulation |
| Molecular mechanism: |
predicted ceRNA regulation via binding hsa-miR-4262 to regulate CACNA2D2 |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation |
| Clinical significance: |
may serve as potential biomarkers of PDCM |
| Description: |
has_circ_0067735 is down-regulated in peripheral blood leukocytes from pediatric dilated cardiomyopathy patients. The study predicts a ceRNA mechanism in which has_circ_0067735 sponges hsa-miR-4262 to influence CACNA2D2, and proposes it as a potential non-invasive biomarker. |
| Confidence score: |
0.4773 |