circRNA basic information
circBase ID: -
Name: hsa_circ_ABCC4
Synonym: circABCC4e
Host Gene: ABCC4
Genomic location(hg19): chr13:95186835-95207889:.
Genomic location(hg38): chr13:94534581-94555635:.
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005086
MONDO name: renal cell carcinoma
Disease details: renal cell carcinoma
Disease DO ID:
 4450
Disease MeSH ID:
 D002292
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

renal carcinoma tissue; plasma; urine; serum
Cell lines:

ACHN; KiMA
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-101-5p, miR-133-5p, miR-138-5p
Biological function: Promotes RCC cell proliferation, migration, invasion, colony formation and xenograft tumor growth; may serve as a diagnostic, prognostic and treatment-response biomarker.
Molecular mechanism: circABCC4e acts as a ceRNA/miRNA sponge that directly antagonizes tumor-suppressive miRNAs miR-101-5p, miR-133-5p and miR-138-5p, thereby promoting RCC progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; RNA Pull-Down; Transfection; Wound Healing Assay; Transwell Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circABCC4e is associated with advanced tumor stages, decreases after tumor resection, and has potential as a diagnostic, prognostic and treatment-response monitoring biomarker for RCC.
Description:

circABCC4e is a human ABCC4-derived circRNA upregulated in RCC tissues, cell lines, plasma and urine, and its levels correlate with advanced tumor stage and decrease after resection. Functionally, circABCC4e promotes RCC cell proliferation, migration, invasion and xenograft growth. Mechanistically, it acts as a ceRNA/miRNA sponge that antagonizes tumor-suppressive miR-101-5p, miR-133-5p and miR-138-5p.
Confidence score:

0.8294
Other information
Title:

Circular RNA circABCC4 as the ceRNA facilitates renal carcinoma progression.

Journal: World journal of urology
Published: 2024
PubMed ID: 39475972
Study type:

combined biological and clinical study
Data availability: available from the corresponding author upon reasonable request; supplementary material available at https://doi.org/10.1007/s00345-024-05279-5
Code availability: -