circRNA basic information
circBase ID: hsa_circ_0038646
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:23999828-24166178:+
Genomic location(hg38): chr16:23988507-24154857:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent normal control tissues
Cell lines:

SW480; HT29; DLD-1; SW620; HCT116; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GRIK3
Associated microRNA: miR-331-3p
Biological function: promotes CRC cell proliferation and migration
Molecular mechanism: Acts as a miRNA sponge for miR-331-3p to increase GRIK3 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Clinical Sample Validation
Clinical significance:

Aberrant hsa_circ_0038646 expression was positively related with increasing tumor grade
Description:

hsa_circ_0038646 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation and migration. Mechanistically, it sponges miR-331-3p, thereby relieving miR-331-3p-mediated repression of GRIK3 and increasing GRIK3 expression.
Confidence score:

0.6369
Other information
Title:

Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3.

Journal: Oncology letters
Published: 2020
PubMed ID: 32565953
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -