circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumors; liver metastases; spleen; liver
Cell lines:

HT29.hCG.Luc; HT29; HCT116.hCG.Luc; HCT116; HEK293T; CMT93.hCG.Luc; CMT93; SW620; Caco-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: Ago2
Associated microRNA: -
Biological function: promotes tumor growth, proliferation and liver metastasis
Molecular mechanism: oncogenic function supported by knockdown/overexpression; mechanism not resolved (miRNA sponge predicted but not validated)
Biological pathway or process:

proliferation (promotes); metastasis (promotes); ceRNA regulation (other)
Detected method:
Q
B
S
Validation methods:

RNA-seq; RT-qPCR; Northern Blot; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Transfection; MTT; In Vivo Animal Model
Clinical significance:

-
Description:

circZNF609 is up-regulated during colorectal cancer progression and metastasis in the xenograft model. Functional gain- and loss-of-function experiments show it promotes tumor growth, cell proliferation, and liver metastasis; the detailed molecular mechanism is not resolved.
Confidence score:

0.6554
Other information
Title:

Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy.

Journal: Cancers
Published: 2020
PubMed ID: 33375322
Study type:

biological research
Data availability: GSE163076
Code availability: -