| Expression pattern: |
UP |
| Associated gene: |
MAP2K6 |
| Associated microRNA: |
miR-375 |
| Biological function: |
promotes KGN cells proliferation; inhibits apoptosis |
| Molecular mechanism: |
circASPH directly targets (sponges) miR-375 and positively regulates MAP2K6 via a ceRNA network |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
thought-provoking biomarkers for PCOS diagnosis and therapy |
| Description: |
circASPH is up-regulated in PCOS granulosa cells and promotes granulosa-like (KGN) cell proliferation while inhibiting apoptosis. Mechanistically, circASPH sponges miR-375 to relieve repression of MAP2K6, forming a circASPH/miR-375/MAP2K6 ceRNA axis with potential diagnostic/therapeutic relevance in PCOS. |
| Confidence score: |
0.6521 |