| Expression pattern: |
DN |
| Associated gene: |
CCDC6, Ago2, FAM53B linear mRNA |
| Associated microRNA: |
miR-183-5p |
| Biological function: |
Circ_FAM53B suppresses PTC cell proliferation, migration, invasion and HUVEC tube formation, promotes apoptosis, and reduces tumor growth in vivo. |
| Molecular mechanism: |
Circ_FAM53B acts as a miR-183-5p sponge and upregulates CCDC6 through miR-183-5p competition, thereby impeding malignant behaviors of PTC cells. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); angiogenesis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; EdU Staining; MTT; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_FAM53B may be a potential biomarker for PTC diagnosis and was correlated with recurrence and lymph node metastasis of tumor samples. |
| Description: |
circ_FAM53B is down-regulated in papillary thyroid carcinoma tissues and cells and is mainly localized in the cytoplasm. It acts as a tumor suppressor by sponging miR-183-5p, thereby increasing CCDC6 expression, which inhibits proliferation, migration, invasion, tube formation and tumor growth while promoting apoptosis. Clinically, circ_FAM53B expression was associated with recurrence and lymph node metastasis and may serve as a potential diagnostic biomarker or therapeutic target in PTC. |
| Confidence score: |
0.8175 |