| Expression pattern: |
UP |
| Associated gene: |
DDR1 |
| Associated microRNA: |
miR-198 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ-PRKDC sponges miR-198 to upregulate DDR1 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ-PRKDC expression was related to TNM stage |
| Description: |
circ-PRKDC (hsa_circ_0136666) is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis and facilitating tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-198, thereby increasing DDR1 expression. |
| Confidence score: |
0.7595 |