| Expression pattern: |
UP |
| Associated gene: |
NOVA2, Ago2 |
| Associated microRNA: |
miR-940 |
| Biological function: |
promotes NSCLC tumorigenesis and metastasis, enhances proliferation, cell cycle progression, migration and invasion, and inhibits apoptosis |
| Molecular mechanism: |
acts as a miRNA sponge for miR-940, thereby upregulating NOVA2 |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high hsa_circ_0046263 could be a predictive marker for poor prognosis of NSCLC patients |
| Description: |
hsa_circ_0046263 is up-regulated in NSCLC and acts as an oncogenic circRNA. It sponges miR-940 to relieve repression of NOVA2, thereby promoting proliferation, cell-cycle progression, migration/invasion and in vivo tumor growth while inhibiting apoptosis, and high expression predicts poorer survival. |
| Confidence score: |
0.8299 |