| Expression pattern: |
UP |
| Associated gene: |
SOX9 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
Promotes oxaliplatin resistance, proliferation, migration, invasion, and tumor growth in gastric cancer cells; knockdown sensitizes cells to oxaliplatin and inhibits tumor growth. |
| Molecular mechanism: |
Exosomal circ_0032821 acts as a ceRNA sponge for miR-515-5p, thereby enhancing SOX9 expression and promoting oxaliplatin resistance in gastric cancer cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Promising therapeutic target for gastric cancer treatment and oxaliplatin resistance. |
| Description: |
Exosomal circ_0032821 is up-regulated in oxaliplatin-resistant gastric cancer cells and their exosomes. It promotes oxaliplatin resistance, proliferation, migration, invasion, and tumor growth by sponging miR-515-5p to increase SOX9 expression, suggesting a potential therapeutic target for gastric cancer chemoresistance. |
| Confidence score: |
0.5627 |