circRNA basic information
circBase ID: hsa_circ_0008717
Name: hsa_circ_ABCB10
Synonym: -
Host Gene: ABCB10
Genomic location(hg19): chr1:229665945-229678118:-
Genomic location(hg38): chr1:229530198-229542371:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC samples; paired para-cancerous tissue specimens; tumor tissue; paired healthy tissue; paired adjacent normal tissues
Cell lines:

SPC-A1; H1975; HCC827; H1650; PC9; A549; 16HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F5
Associated microRNA: miR-584-5p
Biological function: Promotes NSCLC cell proliferation, colony formation, migration, invasion, metastasis and tumor growth; circABCB10 knockdown suppresses NSCLC progression in vitro and in vivo.
Molecular mechanism: CircABCB10 functions as a ceRNA/miRNA sponge for miR-584-5p, thereby up-regulating E2F5 expression and promoting NSCLC progression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circABCB10 expression was associated with low overall survival in NSCLC patients and circRNA-ABCB10 may serve as a predictive biomarker and therapeutic target.
Description:

CircABCB10/hsa_circ_0008717 is up-regulated in NSCLC tissues and cell lines, and high expression predicts poorer survival. Functionally, circABCB10 promotes NSCLC proliferation, colony formation, migration, invasion, metastasis and xenograft tumor growth. Mechanistically, it acts as a miR-584-5p sponge to increase E2F5 expression, forming a circABCB10/miR-584-5p/E2F5 regulatory axis.
Confidence score:

0.7369
Other information
Title:

Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2020
PubMed ID: 32420810
Study type:

combined biological and clinical study
Data availability: GSE97332
Code availability: -