circRNA basic information
circBase ID: hsa_circ_0087862
Name: -
Synonym: circ_0087862
Host Gene: -
Genomic location(hg19): chr9:110068659-110081160:+
Genomic location(hg38): chr9:107306378-107318879:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; corresponding adjacent tissues
Cell lines:

HT29; LoVo; HCT116; DLD-1; HCT8; SW620; FHC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BACH1
Associated microRNA: miR-142-3p
Biological function: Promotes proliferation, migration, and invasion of colorectal cancer cells.
Molecular mechanism: Acts as a ceRNA sponge for miR-142-3p to up-regulate BACH1 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0087862 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-142-3p to up-regulate BACH1.
Confidence score:

0.7283
Other information
Title:

Circ_0087862 promotes the progression of colorectal cancer by sponging miR-142-3p and up-regulating BACH1 expression.

Journal: The Kaohsiung journal of medical sciences
Published: 2021
PubMed ID: 34390174
Study type:

combined biological and clinical study
Data availability: GSE138589
Code availability: -