| Expression pattern: |
DN |
| Associated gene: |
SCUBE2 |
| Associated microRNA: |
miR-155-5p |
| Biological function: |
Represses breast cancer progression by arresting cell cycle, inhibiting proliferation/migration/invasion, and promoting apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-155-5p to upregulate SCUBE2. |
| Biological pathway or process: |
cell cycle (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Luciferase Reporter Assay; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_SETD2 is down-regulated in breast cancer and functions as a tumor suppressor. It sponges miR-155-5p to increase SCUBE2, thereby inhibiting proliferation/migration/invasion, arresting the cell cycle, promoting apoptosis, and suppressing xenograft tumor growth. |
| Confidence score: |
0.7799 |