circRNA basic information
circBase ID: -
Name: hsa_circ_PSD3
Synonym: circRNA pleckstrin and Sec7 domain containing 3
Host Gene: PSD3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; corresponding normal tissues; matched adjacent tissues; normal thyroid tissues
Cell lines:

TPC-1; SW579; BCPAP; Nthy-ori3-1; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: METTL7B, methyltransferase like 7B, PCNA, MMP2, MMP9
Associated microRNA: miR-7-5p
Biological function: circ-PSD3 promotes PTC cell proliferation and invasion; knockdown of circ-PSD3 suppresses proliferation and invasion and reduces PCNA, MMP2, and MMP9 protein levels.
Molecular mechanism: circ-PSD3 acts as a miR-7-5p sponge, reduces miR-7-5p expression, and relieves miR-7-5p-mediated inhibition of METTL7B, thereby increasing METTL7B expression and promoting PTC proliferation and invasion.
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Western Blot; Transwell Assay; Luciferase Reporter Assay
Clinical significance:

circ-PSD3 overexpression was positively associated with larger tumor size, TNM stage, and lymph node metastasis; circ-PSD3 may be a potential diagnostic biomarker, prognostic biomarker, or molecular treatment target for PTC.
Description:

circ-PSD3 is upregulated in human PTC tissues and cell lines and is associated with larger tumor size, advanced TNM stage, lymph node metastasis, and poor clinical prognosis. Functionally, circ-PSD3 promotes PTC cell proliferation and invasion by sponging miR-7-5p and increasing METTL7B expression, suggesting diagnostic, prognostic, and therapeutic potential.
Confidence score:

0.6521
Other information
Title:

circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis.

Journal: Journal of receptor and signal transduction research
Published: 2022
PubMed ID: 33858297
Study type:

combined biological and clinical study
Data availability: GEPIA; TCGA Thyroid Cancer; Starbase; Supplementary Table 1
Code availability: -