circRNA basic information
circBase ID: hsa_circ_0008362
Name: hsa_circ_FBXW4
Synonym: hsa_circFBXW4_008
Host Gene: FBXW4
Genomic location(hg19): chr10:103427642-103436193:-
Genomic location(hg38): chr10:101667885-101676436:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HGG tissues; adjacent normal tissues / adjacent normal brain tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ATP1B1
Associated microRNA: hsa-miR-4656, hsa-miR-217-5p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge (ceRNA) interactions; predicted m6A features
Biological pathway or process:

ceRNA regulation (other); m6A modification (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value in distinguishing HGG from normal tissue (ROC AUC 0.9467).
Description:

hsa_circ_0008362 is down-regulated in HGG compared with adjacent normal tissue and shows strong diagnostic potential by ROC analysis. The study predicts a ceRNA network (e.g., via hsa-miR-217-5p and ATP1B1) and relatively high predicted m6A modification, without functional validation.
Confidence score:

0.6556
Other information
Title:

Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.

Journal: Aging
Published: 2020
PubMed ID: 33323543
Study type:

combined biological and clinical study
Data availability: -
Code availability: -