circRNA basic information
circBase ID: hsa_circ_0000915
Name: hsa_circ_FKBP8
Synonym: hsa_circFKBP8_005
Host Gene: FKBP8
Genomic location(hg19): chr19:18650180-18650530:-
Genomic location(hg38): chr19:18539370-18539720:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HGG tissues; LGG tissues; adjacent normal tissues / adjacent normal brain tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FAIM2
Associated microRNA: hsa-miR-6765-3p, hsa-miR-330-5p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge (ceRNA) interactions; predicted RBPs/ORF/m6A features
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value in distinguishing HGG from LGG (ROC AUC 0.8267).
Description:

hsa_circ_0000915 is down-regulated in HGG compared with LGG and shows diagnostic potential by ROC analysis. The study predicts it may participate in a circRNA-miRNA-mRNA network (e.g., via hsa-miR-330-5p and FAIM2) but does not functionally validate downstream effects.
Confidence score:

0.6556
Other information
Title:

Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.

Journal: Aging
Published: 2020
PubMed ID: 33323543
Study type:

combined biological and clinical study
Data availability: -
Code availability: -