circRNA basic information
circBase ID: hsa_circ_0001806
Name: -
Synonym: circ_0001806
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: cell line
Sample type details: HK2 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TXNIP
Associated microRNA: hsa-miR-942-5p
Biological function: Functional experiments revealed that the miR-942-5p inhibitor could reverse the alleviating effect of circ_0001806 knockdown on LPS-induced HK2 cell injury, and TXNIP addition can also reverse the inhibitory effect of miR-942-5p overexpression on LPS-induced HK2 cell injury.
Molecular mechanism: circ_0001806 can be used as a sponge for miR-942-5p, and miR-942-5p can directly target TXNIP.
Survival: -
Supported No.:
 1
Description:

circ_0001806 knockdown could reduce LPS-induced HK2 cell injury by regulating TXNIP expression via targeting miR-942-5p, indicating that circ_0001806 might be an important biomarker for alleviating sepsis-related AKI.
Other information
Title:

Circ_0001806 relieves LPS-induced HK2 cell injury by regulating the expression of miR-942-5p and TXNIP.

Journal: J Bioenerg Biomembr
Published: 2023/8/5
PubMed ID: 37541979