| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Permits discrimination between pre-eclampsia and trisomy 21 by comparing relative quantities of linear versus circular NRIP1 in first trimester plasma. |
| Molecular mechanism: |
Relative abundance shift between linear NRIP1 and circular NRIP1 in pre-eclampsia; no mechanistic (e.g., ceRNA/protein binding) experiments reported. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Clinical Sample Validation |
| Clinical significance: |
Quantitative assays discriminating linear and circular NRIP1 enable presymptomatic screening of pre-eclampsia and discrimination from trisomy 21. |
| Description: |
This study detected and quantified circular NRIP1 in first-trimester maternal plasma and used the relative balance between linear and circular NRIP1 to help discriminate pre-eclampsia from trisomy 21 in presymptomatic screening. No downstream miRNA/protein/pathway mechanism for circNRIP1 was experimentally established in this paper. |
| Confidence score: |
0.429 |