| Expression pattern: |
UP |
| Associated gene: |
ENTPD4, Ago2 |
| Associated microRNA: |
miR-4319 |
| Biological function: |
promotes proliferation and invasion and suppresses apoptosis; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circATXN7 sponges miR-4319 to regulate ENTPD4 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Back-Splice Junction PCR / divergent primers PCR; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; TUNEL; Transwell Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circATXN7 expression led to a worse prognosis of patients with GC; circATXN7 expression was closely related to TNM stage and pathological type; identified as a new biomarker in GC |
| Description: |
circATXN7 is up-regulated in gastric cancer tissues and cell lines and shows oncogenic effects by promoting proliferation/invasion and inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-4319 to derepress ENTPD4 (circATXN7/miR-4319/ENTPD4 axis), and its knockdown suppresses xenograft tumor growth and metastasis signals. |
| Confidence score: |
0.8871 |