| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
No direct biological function was experimentally validated in this study; hsa_circ_0118464/circRNA-HECW2 was identified as a highly upregulated EAT circRNA in HFpEF and proposed as a candidate for further investigation. |
| Molecular mechanism: |
Expression profiling linked differentially expressed EAT circRNAs to regulation of cellular and metabolic processes; no specific molecular mechanism for hsa_circ_0118464 was experimentally demonstrated. |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May provide insight into diagnostic markers and therapeutic targets in the context of HFpEF. |
| Description: |
hsa_circ_0118464/circRNA-HECW2 is a human EAT circRNA corresponding to HECW2 that was highly upregulated in HFpEF patients. Its upregulation was supported by RNA sequencing and confirmed by qRT-PCR, but its biological mechanism in HFpEF remains unvalidated. |
| Confidence score: |
0.4032 |