circRNA basic information
circBase ID: hsa_circ_0082003
Name: hsa_circ_MET
Synonym: -
Host Gene: MET
Genomic location(hg19): chr7:116339124-116397828:+
Genomic location(hg38): chr7:116699070-116757774:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; matched normal thyroid tissues; adjacent normal thyroid tissues
Cell lines:

Nthy-ori 3-1; B-CPAP; TPC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0082003 promotes PTC cell proliferation, migration, invasion, and xenograft tumor growth, and its high expression is associated with aggressive clinicopathological features including lymph node metastasis.
Molecular mechanism: The exact regulatory mechanism in PTC remains unclear; the study functionally demonstrates an oncogenic role without defining a specific downstream molecular axis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0082003 has potential as a diagnostic biomarker for PTC and as a marker for lymph node metastasis prediction; high expression correlates with adverse clinicopathological parameters and is an independent predictor of LNM.
Description:

This study identifies hsa_circ_0082003, a MET-derived circRNA, as an up-regulated oncogenic circRNA in papillary thyroid carcinoma. Its knockdown suppresses PTC cell proliferation, migration, invasion, and xenograft tumor growth, while high expression is associated with aggressive clinicopathological features and independently predicts lymph node metastasis. The exact downstream regulatory mechanism in PTC was not defined.
Confidence score:

0.7369
Other information
Title:

Microarray profiling identifies hsa_circ_0082003 as a novel tumor promoter for papillary thyroid carcinoma.

Journal: Journal of endocrinological investigation
Published: 2023
PubMed ID: 36115894
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Code availability: -