| Expression pattern: |
UP |
| Associated gene: |
cyclin D1 |
| Associated microRNA: |
miR-195 |
| Biological function: |
Promotes proliferation, migration, invasion and cell cycle progression of PCa cells; promotes tumor growth in vivo. |
| Molecular mechanism: |
circDPP4 functions as a ceRNA (miRNA sponge) for miR-195, reducing miR-195 activity and increasing cyclin D1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; ISH (In Situ Hybridization); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circDPP4 expression was closely associated with Gleason score and clinical stage; high circDPP4 expression had higher Gleason score and more advanced clinical stage. |
| Description: |
circDPP4 (hsa_circ_0056881, derived from DPP4) is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes including proliferation, migration, invasion, and cell cycle progression. Mechanistically, it acts as a ceRNA for miR-195, relieving miR-195-mediated repression of cyclin D1 and thereby enhancing tumor growth. |
| Confidence score: |
0.7916 |