| Expression pattern: |
DN |
| Associated gene: |
Notch1, NF-kappaB signaling |
| Associated microRNA: |
miR-449a |
| Biological function: |
Suppresses proliferation, migration and invasion, and promotes apoptosis of breast cancer cells (tumor suppressive/anti-oncogenic role). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-449a, thereby elevating Notch1 expression and repressing NF-kappaB signaling. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); NF-kappaB (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; circRIP; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Predictor of a poor prognosis of patients with breast cancer. |
| Description: |
circRNA-000911 is down-regulated in breast cancer tissues/cells and functions as a tumor suppressor. It sponges miR-449a, which relieves repression of Notch1 and leads to inhibition of NF-kappaB signaling, thereby reducing proliferation, migration and invasion and promoting apoptosis. |
| Confidence score: |
0.7523 |