| Expression pattern: |
UP |
| Associated gene: |
PI3K/AKT pathway |
| Associated microRNA: |
hsa-miR-1179, hsa-miR-1184, hsa-miR-1205, hsa-miR-127-5p, hsa-miR-1305, hsa-miR-1324, hsa-miR-188-3p, hsa-miR-192, hsa-miR-215, hsa-miR-487a |
| Biological function: |
May promote proliferation and invasion in breast cancer; suggested as a diagnostic biomarker. |
| Molecular mechanism: |
Predicted miRNA sponge mechanism (ceRNA-like), targeting miRNAs involved in PI3K/AKT signaling. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression in BC tissues with diagnostic value by ROC (AUC reported). |
| Description: |
hsa_circ_0005046 is up-regulated in breast cancer tissues and shows diagnostic potential by ROC analysis. Bioinformatics suggests it may act as a miRNA sponge (including miR-215) influencing PI3K/AKT signaling, potentially promoting malignant behaviors. |
| Confidence score: |
0.459 |