| Expression pattern: |
UP |
| Associated gene: |
NID1 |
| Associated microRNA: |
miR-767-3p |
| Biological function: |
Promotes NSCLC tumorigenesis by enhancing proliferation and invasion and inhibiting apoptosis; activates EMT and PI3K/Akt signaling. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-767-3p, thereby regulating NID1 and downstream PI3K/Akt signaling and EMT. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); EMT (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; FISH / smFISH; Western Blot; In Vivo Animal Model; Microarray |
| Clinical significance: |
Associated with metastasis in NSCLC patients; proposed as a biomarker for diagnosis of early stage NSCLC. |
| Description: |
hsa_circ_0018818 is up-regulated in NSCLC and functions as an oncogenic circRNA. Its knockdown suppresses proliferation and invasion and promotes apoptosis, partly by sponging miR-767-3p to regulate NID1 and downstream PI3K/Akt signaling and EMT. |
| Confidence score: |
0.697 |