| Expression pattern: |
UP |
| Associated gene: |
MDM2, P53 |
| Associated microRNA: |
hsa-miR-1273f |
| Biological function: |
promotes paclitaxel resistance and affects apoptosis in NSCLC |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0002874 sponges miR1273f to regulate MDM2 and P53 |
| Biological pathway or process: |
apoptosis (inhibits); chemoresistance (promotes); p53 signaling (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; CCK8; Colony Formation Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
strong expression of hsa_circ_0002874 in NSCLC tissues; increased expression related to advanced TNM stage; potential marker of PTX resistance |
| Description: |
hsa_circ_0002874 is upregulated in NSCLC tissues and is associated with paclitaxel resistance. Mechanistically, it functions as a ceRNA by sponging miR-1273f to modulate the MDM2/P53 signaling, thereby affecting apoptosis and chemosensitivity; knockdown of hsa_circ_0002874 (or miR-1273f overexpression) reverses PTX resistance in vitro and in xenograft models. |
| Confidence score: |
0.7126 |