| Expression pattern: |
UP |
| Associated gene: |
AQP3 |
| Associated microRNA: |
miR-124 |
| Biological function: |
promotes proliferation and migration; promotes xenograft tumor growth |
| Molecular mechanism: |
acts as a miR-124 sponge to regulate the miR-124 target gene AQP3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
high expression level of circHIPK3 was correlated with tumor differentiation; TNM stage; HBV-DNA copy numbers; and the presence of liver cirrhosis |
| Description: |
circHIPK3 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration. Mechanistically, circHIPK3 sponges miR-124 to de-repress the miR-124 target AQP3, and circHIPK3 knockdown suppresses Huh7 xenograft tumor growth via the miR-124-AQP3 axis. |
| Confidence score: |
0.7471 |