| Expression pattern: |
UP |
| Associated gene: |
RAB9A, Ago2, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-411-5p |
| Biological function: |
Promotes osteosarcoma progression and metastasis; enhances proliferation, migration, invasion and cell viability; inhibits apoptosis (silencing increases apoptosis). |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-411-5p to increase RAB9A expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Potential biomarker for osteosarcoma treatment / early diagnosis. |
| Description: |
circSIPA1L1 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes in the cytoplasm. It promotes osteosarcoma proliferation and metastatic phenotypes by sponging miR-411-5p, thereby increasing RAB9A expression; circSIPA1L1 knockdown suppresses tumor growth in vitro and in a xenograft model. |
| Confidence score: |
0.8748 |